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Review Open access Sep 2026

856. Treatment-Resistant Schizophrenia: Definitions, Current Pharmacological Strategies, and Emerging Pipeline Therapies

Abstract Background Antipsychotic monotherapy is the guideline-supported mainstay of treatment for schizophrenia. However, approximately 40% of patients fail to achieve an adequate response in randomized controlled trials, highlighting the significant clinical challenge of treatment-resistant schizophrenia (TRS). Despi...

M. Samara · 0 citations

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