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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

M. Samee

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3 papers indexed here

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Open access Sep 2026

PITX2 missense coding variant expression in mice reveals direct function in atrial fibrillation.

Atrial fibrillation (AF) is the most common sustained human cardiac arrhythmia and linked to a drastic increase in stroke and heart failure risk. While sequence variations in the PITX2 non-coding region are the strongest genetic signature of AF risk, the direct role of PITX2 in AF remains a topic of debate. Here, we ge...

Jeffrey D. Steimle, Yue Yuan, Shao-Hai Fang et al. · 0 citations
Open access Jul 2026

Kernelized approach enables explainable gene prioritizations for complex traits

K-PoPS provides a post hoc framework for examining and interpreting GWAS effector-gene nominations by decomposing each prediction into contributions from training genes, and identifies multiple plausible effector genes within a dilated cardiomyopathy locus contrary to the parsimonious assumption.

Tao-Tao Tan, M. Samee · 0 citations
Open access Jul 2026

SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions

SPARC is presented, a graph-based optimization framework that quantifies similarity in a shared high-dimensional latent space and reconstruct directional trajectories under biological constraints and is the first to propose a “cross-organ bone-like microenvironment” hypothesis.

Shifeng Wu, W. C. Walker, Carolyn A. Martin et al. · 0 citations

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