Open access
Sep 2026
Structural optimization of donepezil-like hybrids toward an improved multi-target and ADME-related profile.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving mainly cholinergic dysfunction, protein misfolding, and metal dyshomeostasis. Considering the complexity of the pathology, multi-target approaches represent a valuable alternative to current approved mono-target treatments. In this study,...
Marco Paparella, R. Leuci, Marco Cerini et al.
· Bioorganic chemistry (Print) · 0 citations