Author

M. Schuldiner

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Open access Oct 2026

A selectivity filter in Tim17 mediates intramitochondrial protein sorting

Mitochondria import hundreds of proteins into the matrix and the inner membrane (IM). The translocase of the IM of mitochondria (TIM23 complex) sorts these proteins using topogenic signals in their structure and directs them into the matrix or inserts them into the IM. How these signals are deciphered is unknown. Her...

Annika Egeler, Sanjoy Paul, Rosario Valenti et al. · Nature Communications · 0 citations

Open access Sep 2026

Swe1 delays cell cycle progression during impaired mitochondrial inheritance to promote mitochondrial homeostasis

Mitochondrial homeostasis is essential for cellular health. To maintain mitochondrial homeostasis in proliferating cells, mitochondrial inheritance to daughter cells must be tightly coordinated with growth and cell division. In budding yeast, mitochondrial inheritance is ensured by active transport into the growing bud...

Lisa Dengler, Igor V. Kukhtevich, Yue Zhang et al. · bioRxiv · 0 citations

Open access Aug 2026

Characterization of Vlf1 as a regulator of lipophagy

Lipid droplets (LDs) are unique organelles, surrounded by a phospholipid monolayer. They are present in most eukaryotic cells including the unicellular model organism S. cerevisiae. LDs store neutral lipids which serve as precursors for amphipathic membrane lipids and as an energy reserve. Loss of LDs in S. cerevisiae...

Zacharias Fakih, Claudia Cavarischia-Rega, Brian Russell Glück et al. · bioRxiv · 0 citations