M. Sedeuil

Msh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids.

Due to a rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is ensured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that specifically control their characteristics, i.e. self-renewal, multipotency and r...