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M. Sentmanat

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Open access Sep 2026

High-order enhancer hubs buffer allelic regulatory variation through kinetic compensation

Diploid genomes carry millions of heterozygous variants in cis-regulatory DNA, yet most genes produce similar RNA output from two parental alleles. How this balance is maintained is unclear. We developed Nanopore-HiChIP, a long-read method that maps high-order enhancer hubs on each haplotype. Over half of these enhance...

Jiang Tan, M. Sentmanat, Yu-Qing Wu et al. · 0 citations

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