Preoperative Prediction of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Multimodal Machine Learning Approach and Implications for Clinical Decision Support
Background. Residual cancer burden (RCB) after neoadjuvant chemotherapy (NAC) offers finer prognostic stratification than binary pathologic complete response, and increasingly guides adjuvant treatment intensity. Predicting four-tier RCB class from preoperative data could inform adjuvant planning before surgery, yet th...