Characterization of mitochondria in trophoblast cells derived from control and early-onset preeclamptic pregnancies via induced pluripotent stem cells.
Early embryonic development occurs in a low oxygen environment, and mitochondrial morphology and function are distinct in embryonic cells and pluripotent stem cells (PSC), which rely less on oxidative phosphorylation than differentiated cells. Oxidative phosphorylation increases with differentiation to trophoblast (TB)...