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Author

M. Shimokawa

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Sep 2026

Production and characterization of a functional anti-mouse PD-1 single-chain variable fragment (scFv) expressed from Bifidobacterium longum 105A.

Bifidobacterium species preferentially accumulate in solid tumors and have emerged as a promising platform for localized production of therapeutic molecules within the tumor microenvironment. In this study, we constructed a recombinant B. longum strain capable of secreting an anti-mouse programmed cell death-1 (PD-1) s...

Rintaro Kubo, M. Shimokawa, Yuri Enomoto et al. · 0 citations

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