Open access
Jul 2026
A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models
Introduction Acute Myeloid Leukemia (AML) is characterized by genetic and epigenetic dysregulation in myeloid progenitor cells. Histone H3 mutations disrupt chromatin and transcription, contributing to disease, but identifying mutations in histone genes is challenging due to sequence duplication. In particular, histone...
Zeinab AlHajj Hassan, H. Dakik, Patricia Arreba-Tutusaus et al.
· Frontiers in Oncology · 0 citations