Evolution of Metal-Based Anticancer Therapeutics: Chemical Foundations, Platinum Drugs, and Emerging Schiff Base Ruthenium(II) and Iridium(III) Complexes
Metal-based chemotherapy has remained a cornerstone of cancer treatment since the clinical introduction of cisplatin; however, systemic toxicity, dose-limiting nephrotoxicity, and acquired resistance continue to limit its therapeutic efficacy. These challenges have stimulated the development of non-platinum-metal-bas...