Open access
Aug 2026
Deconstruction of Aspartic Protease Inhibitors Enables Fragment‐Based Discovery of Plasmepsin V Inhibitors
A structure‐informed, deconstruction‐based approach is applied to identify non‐peptidomimetic PMV inhibitors by mining catalytic dyad‐binding motifs from experimentally solved aspartic protease–inhibitor complexes and assembling a focused fragment‐like library.
M. Skvorcova, Laura Ruduša, D. Zelencova-Gopejenko et al.
· ChemMedChem · 0 citations