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Author

M. Steiger

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Open access Aug 2026

Human brain organoids record the passage of time over multiple years

The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models1. While human brain organoids offer a promising in vitro model, they have...

Irene Faravelli, Noelia Antón-Bolaños, An-Qi Wei et al. · 4 citations
Open access Jul 2026

Genome-wide multi-layered epigenomic profiling across human aging

Deep whole-genome bisulfite sequencing data from blood samples of 120 healthy donors revealed only limited association between age-associated epigenetic alterations in DNA methylation, chromatin accessibility, and histone modifications, arguing against a broadly coordinated remodeling of the aging epigenome.

M. Steiger, René Krüger, Mina Shaigan et al. · 0 citations
Open access Jul 2026

Intraoperative copy number profiling from ultra-low coverage long-read sequencing for molecular tumor assessment

CNVisor is introduced, a statistical framework for reliable and robust CNV detection from long-read sequencing, even under ultra-low coverage, and established real-time CNV profiling using ultra-low coverage nanopore sequencing as a feasible strategy for intraoperative, genomics-informed assessment of CNS tumors.

G. Wang, C. Kubelt, R. Smicius et al. · 0 citations

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