The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models1. While human brain organoids offer a promising in vitro model, they have...
Deep whole-genome bisulfite sequencing data from blood samples of 120 healthy donors revealed only limited association between age-associated epigenetic alterations in DNA methylation, chromatin accessibility, and histone modifications, arguing against a broadly coordinated remodeling of the aging epigenome.
M. Steiger, René Krüger, Mina Shaigan et al.· bioRxiv· 0 citations
CNVisor is introduced, a statistical framework for reliable and robust CNV detection from long-read sequencing, even under ultra-low coverage, and established real-time CNV profiling using ultra-low coverage nanopore sequencing as a feasible strategy for intraoperative, genomics-informed assessment of CNS tumors.
G. Wang, C. Kubelt, R. Smicius et al.· medRxiv· 0 citations
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