Preclinical application and evaluation of an energy-based spectral unmixing method for multi-radionuclide SPECT.
Objective.Crosstalk poses significant challenges in multi-radionuclide SPECT, where γ-rays from one radionuclide are incorrectly attributed to a different radionuclide, compromising image fidelity and interpretations. Although the triple energy window (TEW) method is widely accepted for correcting crosstalk in the acqu...