Systems-level neurophysiologic dysfunction has been documented after acute sport-related concussion in multiple studies over the past quarter century. However, little is known about focal intracortical function post-concussion. We aimed to leverage the high sensitivity of magnetoencephalography (MEG) for the detectio...
Richard Wennberg, A. Potts, Youssef El-Rahimy et al.· Brain Communications· 0 citations
Findings suggest that females may tolerate greater pathology at early stages but experience faster neurodegeneration later, supporting sex‐specific disease trajectories and highlighting the need for sex‐informed biomarkers.
Xu-Lin Liu, S. D. de Boer, M. Tartaglia· Alzheimer's & Dementia· 0 citations
Cognitive and behavioral dysfunction in frontotemporal dementia (FTD) evolves along a clinical continuum from a clinically silent stage of disease, through a prodromal period, often referred to as mild cognitive impairment (MCI) and/or mild behavioral impairment (MBI), and into a clinically manifest stage recognized by...
M. Benatar, E. Huey, Chiadikaobi Onyike et al.· Brain : a journal of neurolo...· 1 citation
OBJECTIVE
Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable and cognitive impact remain under-charact...
H. Alotibi, J. Vargas-Gonzalez, P. Alcaide-Leon et al.· The Canadian journal of neur...· 0 citations
An international workshop was convened in London, Canada in 2025 to review the evidence for existing or evolving biomarkers suitable for the detection of either ALS or FTD pathobiology prior to phenoconversion and/or predict phenoconversion in at risk individuals.
Michael J. Strong, Neil S. Donison, A. Al-Chalabi et al.· Brain : a journal of neurolo...· 0 citations
The model’s accurate estimation of disease stages underscores the value of DEBM for patient stratification, offer a promising tool to support clinical trial design and provide a temporal ordering of multiple CSF proteins.
J. D. De Houwer, Wenjie Kang, Renee van Buuren et al.· Alzheimer's Research & T...· 0 citations
Machine-learning stratification of genetic FTD reveals a progressive and a dissociated disease track and provides individualized progression scores that closely track clinical status, enabling smaller, more efficient prevention and early-intervention trials than conventional MRI or NfL markers alone.
M. Soltaninejad, Y. Iturria-Medina, A. Bouzigues et al.· bioRxiv· 0 citations
Sex and educational attainment significantly affect the development and maintenance of cognitive reserve in individuals with genetic FTD, and underscore the importance of identifying disease-modifying interventions since the presymptomatic stages of the disease.
E. Premi, Damiano Archetti, A. Redolfi et al.· Brain Communications· 0 citations
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