Author

M. Teneche

2 papers indexed here

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Sep 2026

Tumor-derived SAA1-TLR4 signaling drives tumor-to-muscle communication in pancreatic cancer cachexia

Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.

Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini et al. · bioRxiv · 0 citations

Open access Aug 2026

High-Specificity Detection of Chromosomal Mosaicism Reveals Cell-Type-Specific Genomic Alteration Patterns in Aging Tissues

Mosaic chromosomal alterations (mCAs) increase with age and are associated with multiple diseases, yet the cell types and states that harbor these alterations remain largely unknown. Because mCAs arise in individual cells prior to clonal expansion, they are typically rare and obscured in bulk data. We develop CHASM, a...

Xinyi E. Chen, Hanzhi Wang, Yilin Yang et al. · bioRxiv · 0 citations