M. Thastrup

Comparing the Predictive Performance of Machine Learning Models with a Newly Developed Population Pharmacokinetic Model for Busulfan in Paediatric Patients.

BACKGROUND AND OBJECTIVES Busulfan, used in conditioning regimens prior to haematopoietic stem cell transplantation, has a narrow therapeutic index; therefore, due to pharmacokinetic variability, therapeutic drug monitoring (TDM) is employed to ensure drug exposure levels associated with optimal clinical outcomes. This...