M. Tian

Tmlhe deficiency induces neurodevelopmental dysfunction and synaptic excitatory/inhibitory imbalance linked to autism-like phenotypes in zebrafish.

Mutations in TMLHE, the initial enzyme for carnitine biosynthesis, are linked to autism spectrum disorder (ASD). However, the molecular mechanisms by which TMLHE defects contribute to neurodevelopmental abnormalities remain elusive. This study aimed to elucidate the role of tmlhe deficiency in vertebrate neural develop...