Open access
Aug 2026
TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice
Biological sex is a major determinant of Alzheimer’s disease prevalence, yet the molecular mechanisms underlying sex-specific vulnerability remain largely unknown. Metabotropic glutamate receptor 5 (mGluR5) functions as a co-receptor for β-amyloid (Aβ42) oligomer/cellular prion protein (PrPC)-mediated pathogenic signal...
Fatemeh Babaei, Fatemeh A. Panahi, Tash-Lynn L. Colson et al.
· bioRxiv · 0 citations