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M. Todisco

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Open access Sep 2026

A passive protein environment offsets RNA folding energetics in cells

RNA structure can be predicted from sequence in dilute solution, but these predictions often fail in cells. Many cellular RNAs keep their in vitro folds, whereas others are substantially less structured. We combined single-molecule FRET with Xenopus oocyte extract to measure RNA folding and duplex formation under cell-...

M. Todisco, F. Boskovic, A. Jain · 0 citations

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