Author

M. Tomasi

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Open access Oct 2026

Nuclear prohibitin 1 depletion drives alcohol-associated liver injury and sensitization to colon cancer liver metastasis.

Alcohol-associated liver disease (ALD) is associated with higher incidence of colorectal liver metastasis (CRLM); prohibitin 1 (PHB1) defends against CRLM yet its role in ALD and ALD-CRLM is poorly understood and was investigated here. In human, murine, and in vitro ALD models, cytosolic and nuclear PHB1 were depleted,...

Jyoti Chhimwal, Sonal Sinha, Jina Kim et al. · Journal of Clinical Investig... · 0 citations

Open access Sep 2026

Valorization of Sardinian Grapevine Leaves as a Sustainable Source of Flavonols with Anticancer Potential

Grapevine (Vitis vinifera L.) leaves are an abundant agricultural by-product and an underexploited source of bioactive polyphenols. This study characterized hydroalcoholic leaf extracts from autochthonous Sardinian cultivars and evaluated their effects in RKO human colorectal carcinoma cells. LC–HRMS revealed flavonol-...

Ylenia Spissu, M. Tomasi, C. Cossu et al. · Antioxidants · 0 citations