PAMORAs in Cancer and Non-Cancer Opioid-Induced Constipation: A Systematic Review, Meta-Analysis, and Personalized Value-Based Evaluation Integrating Clinical and Patient-Reported Outcomes
Background: Opioid-induced constipation (OIC) is a frequent and clinically relevant complication of long-term opioid therapy in both cancer and non-cancer populations, negatively affecting symptoms, treatment adherence, and health-related quality of life. Peripherally acting μ-opioid receptor antagonists (PAMORAs) repr...