Author

M. V. van Zelm

3 papers indexed here

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Open access Aug 2026

Age and CMV are not associated with clinical or immunological response to immune checkpoint blockade

Ageing and cytomegalovirus (CMV) infection drive major alterations to T-cell immunity. Age is also associated with an increased risk of cancers including melanoma, which is treated with T-cell modifying immune checkpoint blockade (ICB). However, the extent to which age, CMV, and treatment-induced immune changes interac...

J. M. Edwards, S. Senthi, R. Smith et al. · medRxiv · 0 citations

Open access Sep 2026

Impaired memory B-cell formation after mRNA-based COVID-19 booster vaccination in patients with inflammatory bowel disease receiving anti-TNF treatment

Background: Patients receiving anti-TNF treatment for chronic inflammatory disease display impaired antibody responses, but it remains unclear how immune memory formation is affected. We evaluated antibody responses and memory B cells (Bmem) after COVID-19 booster vaccination in inflammatory bowel disease (IBD) patient...

P. A. Gill, L. Bradbury, A. Wang et al. · medRxiv · 0 citations

Open access Aug 2026

Humoral and cellular responses to SARS‐CoV‐2 variants after ancestral COVID‐19 vaccines in people with HIV and lung transplant recipients

Abstract Objectives Immunocompromised hosts have reduced immune responses to COVID‐19 vaccination, and more severe disease. Antibody responses correlate with protection but markers of immunity vary across a spectrum of immunocompromise. We compared serologic and cellular responses following Ancestral COVID‐19 vaccines...

D. Griffin, P. A. Gill, I. Boo et al. · Clinical & Translational Imm... · 0 citations