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Sep 2026

AI Clinical Trials Registered on ClinicalTrials.gov Showed Persistent Misalignment with Global Disease Burden, 2010-2026.

OBJECTIVE To determine whether artificial intelligence (AI) clinical trial activity aligns with global disease burden, and whether the 2023 launch of a global AI health equity initiative was associated with a reorientation of research priorities. STUDY DESIGN AND SETTING We conducted a cross-sectional metaresearch st...

K. Kirby, Caden Forbes, T. Livsey et al. · 0 citations
Open access Sep 2026

Core Outcome Set Measures Are Underreported in Breast Cancer Randomized Clinical Trials: A Cross-Sectional Study.

INTRODUCTION Randomized controlled trials (RCTs) are the gold standard in oncology for the discovery of new therapeutic approaches and treatment management. As medicine takes a more patient-centered approach, patient-reported outcomes (PROs) have become imperative, particularly in clinical trials. The need for standard...

A. Douglas, Ty Moore, Griffin K. Hughes et al. · 0 citations
Review Open access Aug 2026

Safety reporting in chronic kidney disease clinical trials: a comparison of ClinicalTrials.gov registries and published reports

Transparent reporting of adverse events (AEs) is essential for evaluating the safety of interventions from chronic kidney disease (CKD), a population especially vulnerable to treatment-related harm because of polypharmacy, reduced renal clearance, and high comorbidity burden. Since 2007, the FDA Amendments Act (FDAAA 8...

Nevada Denton, Lydia Hashemi, Daniel Archer et al. · 0 citations

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