Open access
Aug 2026
Temperature-driven isoform switching reprograms developmental gene expression in a human fungal pathogen
This work assembles the first isoform-level transcriptome of Histoplasma, a ubiquitous human fungal pathogen that grows as an infectious environmental form (hyphae) or a pathogenic host form (yeast) in response to temperature.
Murat C. Kalem, M. Voorhies, Natalie A. Markman et al.
· bioRxiv · 0 citations