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Open access Sep 2026

Characterization of FLT3-ITD-mutated leukemic stem cells: functional and clinical insights

Despite treatment advances, relapsed/refractory FLT3 -ITD-mutated acute myeloid leukemia ( FLT3 -ITD mut AML) remains an unmet medical need. We previously identified a CD34/CD123/CD25/CD99+ leukemic progenitor cell (LPC) population that persists after induction treatment and drives disease recurrence in FLT3...

S. Travaglini, T. Ottone, S. Antonelli et al. · 0 citations
Open access Sep 2026

Healthcare Utilization Databases for Real-World Outcome Analysis of Ruxolitinib Treatment in Myelofibrosis

Introduction Myelofibrosis (MF) is a BRC::ABL1-negative myeloproliferative neoplasm characterised by a heterogeneous clinical phenotype encompassing abnormalities in blood counts, bone marrow fibrosis, splenomegaly, constitutional symptoms and vascular complications. MF may progress to accelerated phase (AP) and blast...

Barbara Mora, M. Franchi, L. Margotto et al. · 0 citations

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