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Open access Sep 2026

Switching apo- and holo-IscR control of LcrF alters how iron and oxygen regulate Yersinia virulence factors

ABSTRACT Iron and oxygen availability fluctuate spatially across mammalian tissues as well as temporally during bacterial infection. The [2Fe-2S] cluster-coordinating transcription factor IscR senses changes in iron and oxygen levels and plays a pivotal role in how Yersinia, Salmonella, and Vibrio regulate critical vir...

Mané Ohanyan, G. I. Balazs, Karthik Hullahalli et al. · 0 citations
Open access Sep 2026

Dual roles of host N-glycosylation in enteropathogenic Escherichia coli infection.

Host factors determine pathogen tropism but knowledge of host genes facilitating enteropathogenic Escherichia coli (EPEC) infection is limited. To identify host determinants required for infection by EPEC, we performed two independent genome-scale CRISPR-Cas9 screens. Both converged on host N-glycosylation as a critica...

Klil Cohen-Yaron, Yaakov Socol, Noam Yedidi et al. · 0 citations

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