Neuroplasticity, the brain’s capacity to reorganise its structure and function, is a transdiagnostic feature across psychiatric and neurodegenerative diseases and a putative mechanism of action for pharmacological interventions. [¹¹C]-UCBJ positron emission tomography (PET), which quantifies synaptic vesicle glycoprote...
C. Agnorelli, J. Peill, D. Kurtin et al.· bioRxiv· 0 citations
Abstract Background Clinical studies have shown that ketamine and classic psychedelics can produce robust and rapid antidepressant effects after a single or a few administrations. However, the neurobiological mechanisms driving these long-lasting changes remain unclear. A leading framework proposes that both drug class...
C. Agnorelli, J. Peill, D. Kurtin et al.· International Journal of Neu...· 0 citations
Findings are broadly consistent with corticostriatal models of GD and identify candidate circuit-level differences for independent replication, but larger, more diverse and longitudinal samples are required to establish their reproducibility, temporal direction and clinical relevance.
Rayyan Zafar, N. Ertl, Luke Donegan et al.· bioRxiv· 0 citations
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