Estradiol regulates L-type calcium channel-dependent social behavior deficits during cocaine abstinence in female rats.
Social withdrawal during cocaine abstinence is a significant predictor of relapse, yet the neuroendocrine mechanisms underlying this vulnerability remain poorly understood, particularly in females. Estradiol, a potent neuromodulator of mesocorticolimbic circuitry, regulates dopamine-dependent processes that encode soci...