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Sep 2026

Cardiovascular-kidney-metabolic syndrome and the risk of liver-related and cardiovascular events across the steatotic liver disease spectrum.

BACKGROUND Steatotic liver disease (SLD) is closely associated with cardiometabolic factors, but whether the cardiovascular-kidney-metabolic (CKM) stage stratifies risk for major adverse cardiovascular events (MACEs) and liver-related events (LREs) across SLD subtypes remains unclear. METHODS In the UK Biobank study,...

Qiong-Yue Fan, Li-You Lian, Tian-Yi Xia et al. · 0 citations
Aug 2026

Activation of the KPNA2-mediated nuclear import of PPARα by KIF13B mitigates alcohol-associated liver steatosis.

BACKGROUND Alcohol-associated liver disease (ALD) is a major global health burden with no approved targeted therapies. Emerging evidence implicates kinesin family member 13B (KIF13B) in lipid metabolism, primarily in cardiovascular disease but its role in ALD remains unexplored. OBJECTIVE To investigate the role and...

Kai-Kai Lu, Si Mei, Lian-Xing Zhang et al. · 0 citations

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