Sep 2026
Abstract B070: Adaptive KRAS-MAPK signaling mediates resistance to CD73 blockade in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains highly refractory to therapy due to oncogenic KRAS signaling and an immunosuppressive tumor microenvironment. We previously established that CD73 is induced early during pancreatic tumorigenesis, where extracellular adenosine promotes disease progression through ADO...
Khadija Turabi, Shwetapadma Dash, Lincoln N. Strickland et al.
· Cancer Research · 0 citations