Madeleine R. Keller

Genetically inducible coordinators of cytokine signaling pathways for interrogating T cell motility

Chimeric antigen receptor (CAR) T cell therapy is promising for treating hematologic malignancies, but extending this success to treat solid tumors is challenging. Improving T cell phenotype to address this need is desirable, and one such property is increasing T cell infiltration into tumors. A promising potential app...