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Author

Madhav Jagannathan

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Open access Aug 2026

Nuclear stress bodies enable a germline-specific transcriptional stress response in Drosophila

The germline ensures the continuity of genetic information across generations, but how this immortal lineage functions under stress conditions remains incompletely understood. Here, we identify that heat shock factor (Hsf), a conserved master regulator of the stress response, drives the expression of transposable eleme...

Dhanashree Lakhe, Lorenzo Gallicchio, Juan Sebastian Ochoa Gutierrez et al. · 0 citations
Open access Aug 2026

The dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesis.

DYT1 dystonia is an incurable movement disorder caused by a loss-of-function mutation in Torsin1A, an endoplasmic reticulum (ER)-resident AAA+ ATPase. Here, we use Drosophila and human cells to shed light on Torsins' mode of action. Fly germ cells lacking dTorsin arrest in development with defects in nuclear pore compl...

D. Maslennikova, Harry J. M. Baird, Xinyue Ding et al. · 2 citations · ⚡1

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