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Author

Maeve L. Troost

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Open access Aug 2026

IL1A promotes inflammation while safeguarding epithelial basal cell identity and barrier function.

These findings demonstrate that IL1A coordinates epithelial inflammatory and regenerative responses in the human esophagus, and show that the outcome of IL1A signaling is determined by the surrounding inflammatory milieu, providing a framework for understanding epithelial remodeling in eosinophilic esophagitis.

E. Eenjes, Maeve L. Troost, L. Lei et al. · 0 citations
Open access Aug 2026

CRISPR/dCas9-mediated tuning of DMPK transcription reveals a quantitative relationship between toxic repeat RNA expression and MBNL1 activity in myotonic dystrophy.

It is demonstrated that expanded DMPK transcript levels modulate free MBNL1 concentration and alternative splicing in a dose-dependent manner, underscoring the central role of repeat RNA expression in DM1 pathogenesis.

Lise Ripken, Thomas D. Hoekman, M. Willemse et al. · 0 citations

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