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Author

Magdi E. A. Zaki

2 papers indexed here

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Open access Sep 2026

Quinazoline-tethered thiazolo[3,2-a]pyrimidines and their cyclic chalcone derivatives as HIV-1 reverse transcriptase inhibitors: green synthesis, molecular docking, and in silico studies

Nitrogen-fused heterocycles have attracted considerable research interest in pharmaceutical, medicinal, organometallic, and materials chemistry. In this work, two new series of quinazoline-linked thiazolo[3,2-a]pyrimidines and their cyclic chalcone derivatives were synthesized using choline hydroxide as an environmenta...

S. M. Gomha, Sami A. Alhussain, Yaser A. M. Sulaiman et al. · 0 citations
Open access Sep 2026

Quinazolinone–diarylpyrazole hybrids as dual EGFR/COX-2 inhibitors: antiproliferative, mechanistic, and in silico studies

Abnormal epidermal growth factor receptor (EGFR) signaling and cyclooxygenase-2 (COX-2) mediated inflammatory pathways contribute to tumor progression and survival, supporting their simultaneous pharmacological targeting. Herein, a series of quinazolinone–diarylpyrazole hybrids 7a–l was designed, synthesized, and evalu...

Abdullah Alkhammash, B. A. Saleem, Khulood H. Oudah et al. · 0 citations

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