Jul 2026
Systematic Targeting of Protein Complexes with Molecular COUPLrs
Small molecules that modulate protein complexes have transformed cell biology and oncology, yet few chemical starting points exist to probe protein-protein interactions. To expand this space, we developed molecular COUPLrs, elaborated small molecules flanked by two cysteine-reactive warheads. Using CONNECT, an integrat...
Diane Yang, S. Harry, H. Chong et al.
· Cancer Discovery · 0 citations