Alzheimer’s disease (AD) is characterized by heterogeneous Tau phosphorylation and aberrant amyloid-β (Aβ) processing, yet molecular tools that distinguish closely related molecular states of tau and Aβ with predefined specificity remain difficult to develop. Here, we designed de novo protein readers targeting three di...
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed genetically encoded miniproteins capable of activating or inhibiting focal adhesion kinase (FAK) by directly targeting...
Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino et al.· bioRxiv· 0 citations
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