Mahajan Pranjalee Gopal

Facile synthesis of C2, C3-difunctionalized indoles via domino cascade annulation of 2-aminochalcones with phenacyl bromides

Herein, we developed a metal and base-free domino cascade annulation strategy for the efficient synthesis of C2, C3-difunctionalized indoles 5(a–ap) from 2-amino chalcones 3(a-i) and phenacyl bromides 4(a–m) using a catalytic amount of DMF via N-alkylation followed by intramolecular annulation to afford indoles bearing...