The protein-water H-bond network for bacterial response regulator REC domain activation
The bacterial response regulator (RR) superfamily is activated by aspartyl phosphorylation of the receiver (REC) domain for diverse functions. Crystal structures of the enteric CheY chemotaxis RRs (CheYes) have revealed water-residue hydrogen bonds (H-bonds) essential for activation. Here, we compared the H-bond networ...