Efinaconazole-Loaded Liposomal Nanocarriers: A Box-Behnken Design Approach in Formulation Designing and Optimization for Onychomycosis.
OBJECTIVE To design, optimize, and evaluate efinaconazole-loaded liposomal formulation with sustained drug release, enhanced trans-ungual drug penetration, and improved drug retention for treatment of onychomycosis. SIGNIFICANCE Conventional topical therapies for onychomycosis are limited by poor nail permeability an...