Maho Niwa

Decoding the impact of lipid saturation on ER signaling networks, ERSU, UPR, and ERAD

The faithful inheritance of a functional endoplasmic reticulum (ER) in Saccharomyces cerevisiae is safeguarded by the ER Stress Surveillance (ERSU) checkpoint, which delays cytokinesis when ER homeostasis is perturbed. Under stress, ER transmission to the daughter cell is halted, while in parallel—but through independe...