Author

Mai-Li Liu

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Aug 2026

Photo-CIDNP-Enhanced 19F NMR for Rapid Protein Conformation and Ligand Binding Analysis.

19F NMR spectroscopy is a powerful probe of protein conformation and dynamics but is intrinsically limited by low sensitivity common to other NMR techniques. Here, we integrate photochemically induced dynamic nuclear polarization (photo-CIDNP) with genetically encoded 19F labels to enhance sensitivity by up to 220-fold...

Zhao-Fei Chai, Weixuan Wang, Qiong Wu et al. · Journal of the American Chem... · 1 citation

Open access Aug 2026

Assessing G-Quadruplex Stability and Nonspecific Interactions in Living Cells Using 19F NMR

G-quadruplex (G4) structures play key physiological roles and serve as functional building blocks in DNA/RNA-based aptamer biosensors. Their function critically depends on their structural stability and nonspecific interactions in cells. However, the behavior of exogenously delivered G4s in living cells remains poorl...

Qiong Wu, Wen-Wen Zheng, Chen Wang et al. · JACS Au · 0 citations

Open access Aug 2026

High-quality pure shift NMR spectra by deep learning using multi-spectral input and joint loss functions

Pure shift methods greatly improve the resolution of nuclear magnetic resonance (NMR) spectra, aiding in the subsequent spectral analysis. However, existing approaches typically compromise sensitivity, introduce artifacts, or distort the signal integrals needed to quantify the amount of each component in a sample. Here...

Wei Cai, Yi-Yang Li, Xiaoxu Zheng et al. · Nature Communications · 0 citations