Open access
Sep 2026
Striatal 6-hydroxydopamine lesion in rats induces dysregulation of the gut barrier.
Gastrointestinal (GI) dysfunction is a well-recognized prodromal feature of Parkinson's disease (PD), yet the mechanisms linking central dopaminergic (DA) neurodegeneration to gut pathology remain unclear. Previous studies have reported intestinal permeability and microbiome changes in toxin-based PD models, but the sp...
Cassandra J. Kaufhold, Kaylin A. Pickle, Debanjana Das et al.
· Experimental Neurology · 0 citations