Maikel Acosta-Zaldívar

Cascading damage to Candida albicans cells through thioredoxin reductase loss

Candida albicans is the most common invasive human fungal pathogen. We show that C. albicans thioredoxin reductase, Trr1, is an attractive antifungal target: it is essential at human body temperature, and fungal and human thioredoxin reductases are structurally divergent, predicting high selectivity of fungal-targeted...