Aug 2026
Design and synthesis of novel thiazolotriazole-sulfonamide hybrids tackling antimicrobial resistance: mechanistic insights into efflux pump inhibitor, gene downregulation, and machine-aided results.
The escalating global threat of antimicrobial resistance necessitates innovative therapeutic strategies. In this study, a novel series of thiazolotriazole-sulfonamide hybrids was designed using a molecular hybridization strategy. Computational potency was predicted via pharmacophore modelling, identifying biologically...
Hossam H. Elsayed, Eman Z. Elrazaz, Maiy Y Jaballah et al.
· Bioorganic chemistry (Print) · 0 citations