From gut-derived metabolites to topical targets: 5-(3',4'-dihydroxyphenyl)-γ-valerolactone as an anti-inflammatory candidate for skin and mucosal inflammation.
Plant-derived compounds can be transformed by the human gut microbiota into postbiotic metabolites with distinct structures and biological activities, providing insight into the mechanisms underlying the pharmacological effects of medicinal plants. Among them, 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (DHPV), a microbi...