Maliheh Barazandeh Tehrani

Aniline-linked coumarin-triazole hybrids as α-glucosidase inhibitors: An insightful study from synthesis to in vivo efficacy and mechanistic analysis.

A new series of coumarin-aniline-triazole hybrids 12a-p was prepared using a multi-step approach. This synthesis involved a Knoevenagel condensation between 2-hydroxybenzaldehyde and diethyl malonate, followed by ester hydrolysis and amide coupling to yield a coumarin-based alkyne, which was then reacted with various 2...