Injectable polysaccharide-based composite hydrogel promotes regeneration of critical-sized bone defects.
The development of a minimally invasive, injectable, and fully biocompatible hydrogel (CCD@HapSi), formed via a simple Schiff-base reaction between carboxymethyl chitosan and oxidized dextran, which promotes substantial bone regeneration in a critical sized calvarial defect, significantly outperforming control groups.