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Mallikarjun Koganti

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Open access Oct 2026

Highly Sensitive LC–QTOF‐MS Method Development and Validation for Trace Level Determination of N ‐Nitroso Tizanidine in Tizanidine Drug Substance and Formulations

Nitrosamine drug substance–related impurities have been a central focus of regulatory scrutiny due to their potential mutagenic and carcinogenic effects. Among these, N ‐nitroso tizanidine ( N ‐NTZD) is a possible impurity that may form during the manufacturing, processing, or storage of tizanidine (TZD) drug s...

Mallikarjun Koganti, Ramesh Kola, Haritha Reddy Nagidi · 0 citations

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