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Author

Malte Simon

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Open access Aug 2026

Characterization and pharmacological modulation of Alzheimer’s disease-associated human microglial states

This work integrated single-nucleus transcriptomic datasets across the AD spectrum and identified DLaM as a major AD-enriched population linked to genetic risk, neuropathology and cognitive decline, and identified LY2090314 as a potent modulator that restored microglial function and induced a distinct lysosomal-metabol...

G. Garcia-Diaz Barriga, Daniel Rosebrock, Henrik Renner et al. · 0 citations

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